| HMGA2 |
| LOCUS ID | 8091 | ||||||||||
| GENE_SYMBOL | HMGA2 | ||||||||||
| GENE NAME | high mobility group | ||||||||||
| SYNONYMNS | BABL, LIPO, HMGIC, HMGI-C, STQTL9 | ||||||||||
| CHROMOSOME | 12 | ||||||||||
| HOMOLOGENE ID | 136767 |
| microRNAs | NA | NA |
| GENE SUMMARY |
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| This gene encodes a protein that belongs to the non-histone chromosomal high mobility group (HMG) protein family. HMG proteins function as architectural factors and are essential components of the enhancesome. This protein contains structural D-binding domains and may act as a transcriptional regulating factor. Identification of the deletion, amplification, and rearrangement of this gene that are associated with myxoid liposarcoma suggests a role in adipogenesis and mesenchymal differentiation. |
| OBSERVATIONS |
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| Complication | Evidence | PMID |
| Nephropathy | 1. These data demonstrate that the HMGA2 variant seems to be associated with increased risk of developing nephropathy in patients with type 2 diabetes and lower eGFR in both diabetic and non-diabetic individuals and could thus be a common denominator in the pathogenesis of type 2 diabetes and kidney complications. | 23111731 |