| HRH1 |
| LOCUS ID | 3269 | ||||||||||
| GENE_SYMBOL | HRH1 | ||||||||||
| GENE NAME | histamine receptor H | ||||||||||
| SYNONYMNS | H1R, H1-R, HH1R, hisH1 | ||||||||||
| CHROMOSOME | 3 | ||||||||||
| HOMOLOGENE ID | 668 |
| microRNAs | NA | NA |
| GENE SUMMARY |
|---|
| Histamine is a ubiquitous messenger molecule released from mast cells, enterochromaffin-like cells, and neurons. Its various actions are mediated by histamine receptors H1, H2, H3 and H4. The protein encoded by this gene is an integral membrane protein and belongs to the G protein-coupled receptor superfamily. It mediates the contraction of smooth muscles, the increase in capillary permeability due to contraction of termil venules, the release of catecholamine from adrel medulla, and neurotransm |
| OBSERVATIONS |
|---|
| Complication | Evidence | PMID |
| Neuropathy | 1.combination H1 and H2 receptor antagonist therapy in diabetic autonomic neuropathy. | 6123154 |