| HSD11B1 |
| LOCUS ID | 3290 | ||||||||||
| GENE_SYMBOL | HSD11B1 | ||||||||||
| GENE NAME | hydroxysteroid 11-be | ||||||||||
| SYNONYMNS | HDL,11-DH,HSD11,HSD11B,HSD11L,CORTRD2,SDR26C1,11-beta-HSD1 | ||||||||||
| CHROMOSOME | 1 | ||||||||||
| HOMOLOGENE ID | 68471 |
| microRNAs | NA | NA |
| GENE SUMMARY |
|---|
| The protein encoded by this gene is a microsomal enzyme that catalyzes the conversion of the stress hormone cortisol to the inactive metabolite cortisone. In addition, the encoded protein can catalyze the reverse reaction, the conversion of cortisone to cortisol. Too much cortisol can lead to central obesity, and a particular variation in this gene has been associated with obesity and insulin resistance in children. Mutations in this gene and H6PD (hexose-6-phosphate dehydrogenase (glucose 1-deh |
| OBSERVATIONS |
|---|
| Complication | Evidence | PMID |
| Insulin resistance and inflammation | 1. Hence, 11beta-HSD1 acts at the interface of inflammation and obesity and represents an efficient integrator and effector of local inflammatory and metabolic state. | 20045052 |