| HSPB1 |
| LOCUS ID | 3315 | ||||||||||
| GENE_SYMBOL | HSPB1 | ||||||||||
| GENE NAME | heat shock 27kDa pro | ||||||||||
| SYNONYMNS | CMT2F, HMN2B, HSP27, HSP28, Hsp25, SRP27, HS.76067 | ||||||||||
| CHROMOSOME | 7 | ||||||||||
| HOMOLOGENE ID | 1180 |
| microRNAs | NA | NA |
| GENE SUMMARY |
|---|
| The protein encoded by this gene is induced by environmental stress and developmental changes. The encoded protein is involved in stress resistance and actin organization and translocates from the cytoplasm to the nucleus upon stress induction. Defects in this gene are a cause of Charcot-Marie-Tooth disease type 2F (CMT2F) and distal hereditary motor neuropathy (dHMN). [provided by RefSeq, Oct 2008] |
| OBSERVATIONS |
|---|
| Complication | Evidence | PMID |
| Nephropathy | 1. both high glucose and Ang II contribute to HSPB1 upregulation. HSPB1 upregulation allows podocytes to better withstand an adverse high-glucose or Ang II-rich environment, such as can be found in DN. | 21931298 |