| HTR2A |
| LOCUS ID | 3356 | ||||||||||
| GENE_SYMBOL | HTR2A | ||||||||||
| GENE NAME | 5-hydroxytryptamine | ||||||||||
| SYNONYMNS | HTR2, 5-HT2A | ||||||||||
| CHROMOSOME | 13 | ||||||||||
| HOMOLOGENE ID | 68473 |
| microRNAs | NA | NA |
| GENE SUMMARY |
|---|
| This gene encodes one of the receptors for serotonin, a neurotransmitter with many roles. Mutations in this gene are associated with susceptibility to schizophrenia and obsessive-compulsive disorder, and are also associated with response to the antidepressant citalopram in patients with major depressive disorder (MDD). MDD patients who also have a mutation in intron 2 of this gene show a significantly reduced response to citalopram as this antidepressant downregulates expression of this gene. Mu |
| OBSERVATIONS |
|---|
| Complication | Evidence | PMID |
| Nephropathy | 1. Since recent reports have demonstrated the presence of 5-HT2A receptor in glomerular mesangial cells, it is possible that 5-HT may be involved in the development of diabetic nephropathy through the 5-HT2A receptor in mesangial cells. | 9767524 |