| HYOU1 |
| LOCUS ID | 10525 | |||||||||||||
| GENE_SYMBOL | HYOU1 | |||||||||||||
| GENE NAME | hypoxia up-regulated | |||||||||||||
| SYNONYMNS | Grp170, HSP12A, ORP150, GRP-170, ORP-150 | |||||||||||||
| CHROMOSOME | 11 | |||||||||||||
| HOMOLOGENE ID | 4658 |
| microRNAs | NA | NA |
| GENE SUMMARY |
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| The protein encoded by this gene belongs to the heat shock protein 70 family. This gene uses alternative transcription start sites. A cis-acting segment found in the 5' UTR is involved in stress-dependent induction, resulting in the accumulation of this protein in the endoplasmic reticulum (ER) under hypoxic conditions. The protein encoded by this gene is thought to play an important role in protein folding and secretion in the ER. Since suppression of the protein is associated with acceler |
| OBSERVATIONS |
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| Complication | Evidence | PMID |
| Nephropathy | 1. Immunofluorescence of renal biopsies from patients with DN confirmed the upregulation for HSPA5 and HYOU1 proteins in tubular epithelia. | 18776125 |
| Neuropathy | 1. In vivo knockdown of ORP150 induced DPN in early diabetes and exacerbated the DPN after prolonged diabetes, whereas knockdown of CHOP ameliorated DPN in rats with prolonged diabetic. | 23988440 |