| IAPP |
| LOCUS ID | 3375 | ||||||||||
| GENE_SYMBOL | IAPP | ||||||||||
| GENE NAME | islet amyloid polype | ||||||||||
| SYNONYMNS | DAP,IAP | ||||||||||
| CHROMOSOME | 12 | ||||||||||
| HOMOLOGENE ID | 36024 |
| microRNAs | NA | NA |
| GENE SUMMARY |
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| This gene encodes a member of the calcitonin family of peptide hormones. This hormone is released from pancreatic beta cells following food intake to regulate blood glucose levels and act as a satiation signal. Human patients with type 1 and advanced type 2 diabetes exhibit reduced levels of the encoded hormone in blood and pancreas. This protein also exhibits a bactericidal, antimicrobial activity. [provided by RefSeq, Jul 2016] |
| OBSERVATIONS |
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| Complication | Evidence | PMID |
| Insulin resistance and inflammation | 1. In cultured islets, macrophages (F4/80(+)CD11b(+)CD11c(+) cells) were required for IAPP-induced mRNA expression of the proinflammatory cytokines IL-1?, tumor necrosis factor-?, and IL-6 and the anti-inflammatory cytokines IL-10 and IL-1 receptor antagonist. | 24222351 |