| ICAM1 |
| LOCUS ID | 3383 | |||||||||||||
| GENE_SYMBOL | ICAM1 | |||||||||||||
| GENE NAME | intercellular adhesi | |||||||||||||
| SYNONYMNS | BB2, CD54, P3.58 | |||||||||||||
| CHROMOSOME | 19 | |||||||||||||
| HOMOLOGENE ID | 168 |
| microRNAs | NA | NA |
| GENE SUMMARY |
|---|
| This gene encodes a cell surface glycoprotein which is typically expressed on endothelial cells and cells of the immune system. It binds to integrins of type CD11a / CD18, or CD11b / CD18 and is also exploited by Rhinovirus as a receptor. [provided by RefSeq, Jul 2008] |
| OBSERVATIONS |
|---|
| Complication | Evidence | PMID |
| Nephropathy | 1. The present study provided evidence that the ICAM1 K469E(A/G) polymorphism with high heterozygous index and elevation of plasma ICAM-1 levels were associated with DN in a Malaysian population. Further prospective study of ICAM-1 protein according to the ICAM1 K469E(A/G) genotypes is necessary for predicting the susceptibility to T2D and DN. | 26255081 |
| Atherosclerosis | 1. Experiments in isolated endothelial cells from Foxo1(KR/KR) mice indicate that deacetylation favors FoxO1 nuclear accumulation and exerts target gene-specific effects, ing in higher Icam1 and TnfA expression and increased monocyte adhesion. The data indicate that FoxO1 deacetylation can promote vascular endothelial changes conducive to atherosclerotic plaque formation. | 22389493 |