| ID1 |
| LOCUS ID | 3397 | ||||||||||
| GENE_SYMBOL | ID1 | ||||||||||
| GENE NAME | inhibitor of D bindi | ||||||||||
| SYNONYMNS | ID, bHLHb24 | ||||||||||
| CHROMOSOME | 20 | ||||||||||
| HOMOLOGENE ID | 168 |
| microRNAs | miR-26a | 26776318 |
| GENE SUMMARY |
|---|
| The protein encoded by this gene is a helix-loop-helix (HLH) protein that can form heterodimers with members of the basic HLH family of transcription factors. The encoded protein has no D binding activity and therefore can inhibit the D binding and transcriptional activation ability of basic HLH proteins with which it interacts. This protein may play a role in cell growth, senescence, and differentiation. Two transcript variants encoding different isoforms have been found for this gene. [provide |
| OBSERVATIONS |
|---|
| Complication | Evidence | PMID |
| Nephropathy | 1. These data suggest that Scx and Id1 are involved in the BMP4-Smad1-SMA signal transduction pathway besides the TGFBeta1-Smad1-SMA signaling pathway and modulate phenotypic changes in MCs in diabetic nephropathy. | 22474292 |