| IFI16 |
| LOCUS ID | 3428 | ||||||||||
| GENE_SYMBOL | IFI16 | ||||||||||
| GENE NAME | interferon gamma ind | ||||||||||
| SYNONYMNS | PYHIN2 IFNGIP1 | ||||||||||
| CHROMOSOME | 1 | ||||||||||
| HOMOLOGENE ID | 115929 |
| microRNAs | NA | NA |
| GENE SUMMARY |
|---|
| This gene encodes a member of the HIN-200 (hematopoietic interferon-inducible nuclear antigens with 200 amino acid repeats) family of cytokines. The encoded protein contains domains involved in DNA binding, transcriptional regulation, and protein-protein interactions. The protein localizes to the nucleoplasm and nucleoli, and interacts with p53 and retinoblastoma-1. It modulates p53 function, and inhibits cell growth in the Ras/Raf signaling pathway. Alternatively spliced transcript variants enc |
| OBSERVATIONS |
|---|
| Complication | Evidence | PMID |
| Insulin resistance and inflammation | 1. Suppression of IFI202b/IFI16 in pre-adipocytes impaired adipocyte differentiation and triacylglycerol storage. | 29478099 |