| IFNAR1 |
| LOCUS ID | 3454 | ||||||||||
| GENE_SYMBOL | IFNAR1 | ||||||||||
| GENE NAME | interferon alpha and | ||||||||||
| SYNONYMNS | AVP IFRC IFNAR IFNBR IFN-alpha-REC | ||||||||||
| CHROMOSOME | 21 | ||||||||||
| HOMOLOGENE ID | 524 |
| microRNAs | NA | NA |
| GENE SUMMARY |
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| The protein encoded by this gene is a type I membrane protein that forms one of the two chains of a receptor for interferons alpha and beta. Binding and activation of the receptor stimulates Janus protein kinases, which in turn phosphorylate several proteins, including STAT1 and STAT2. The protein belongs to the type II cytokine receptor family and functions as an antiviral factor. [provided by RefSeq, Jul 2020] |
| OBSERVATIONS |
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| Complication | Evidence | PMID |
| Insulin resistance and inflammation | 1. In contrast, adipose-specific, but not hepatocyte-specific deletion of Ifnar1 deteriorated metabolic dysregulation induced by a high-fat diet, indicated by increased weight gain, insulin resistance and an impaired glucose tolerance. | 28011892 |