| IFNL1 |
| LOCUS ID | 282618 | ||||||||||
| GENE_SYMBOL | IFNL1 | ||||||||||
| GENE NAME | interferon lambda 1 | ||||||||||
| SYNONYMNS | IL29 IL-29 | ||||||||||
| CHROMOSOME | 19 | ||||||||||
| HOMOLOGENE ID | 131189 |
| microRNAs | NA | NA |
| GENE SUMMARY |
|---|
| This gene encodes a cytokine distantly related to type I interferons and the IL-10 family. This gene, interleukin 28A (IL28A), and interleukin 28B (IL28B) are three closely related cytokine genes that form a cytokine gene cluster on a chromosomal region mapped to 19q13. Expression of the cytokines encoded by the three genes can be induced by viral infection. All three cytokines have been shown to interact with a heterodimeric class II cytokine receptor that consists of interleukin 10 receptor, b |
| OBSERVATIONS |
|---|
| Complication | Evidence | PMID |
| Insulin resistance and inflammation | 1. we have identified a critical role of IL-29 in obesity-induced inflammation and insulin resistance, and we conclude that IL-29 may be a novel candidate target for treating obesity and insulin resistance in patients with metabolic disorders. | 31363171 |