| IGF1R |
| LOCUS ID | 3480 | ||||||||||||||||
| GENE_SYMBOL | IGF1R | ||||||||||||||||
| GENE NAME | insulin like growth | ||||||||||||||||
| SYNONYMNS | IGFR, CD221, IGFIR, JTK13 | ||||||||||||||||
| CHROMOSOME | 15 | ||||||||||||||||
| HOMOLOGENE ID | 30997 |
| microRNAs | NA | NA |
| GENE SUMMARY |
|---|
| This receptor binds insulin-like growth factor with a high affinity. It has tyrosine kinase activity. The insulin-like growth factor I receptor plays a critical role in transformation events. Cleavage of the precursor generates alpha and beta subunits. It is highly overexpressed in most malignt tissues where it functions as an anti-apoptotic agent by enhancing cell survival. Altertively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, May |
| OBSERVATIONS |
|---|
| Complication | Evidence | PMID |
| Retinopathy | 1. our study indicated IGF1 and IGF1R differential expression in ERMs, but not in PBMCs, of diabetic and nondiabetic patients, suggesting that these factors can be involved in the pathogenesis or progression of proliferative vitreoretinal disorders. | 24379526 |
| Nephropathy | 1. Inhibition of IGF1R was a more effective choice for inflammation treatment than Ben or Ins in diabetic kidney disease (DKD). The IGF1R inhibitor blocked pathological changes induced by the over-expression of IGF1 in DKD without up-regulating SOCS2 protein levels. | 30254418 |
| Insulin resistance and inflammation | 1. IGF1R expression was increased in aortas from diabetic mice. | 19122171 |