| IGFBP1 |
| LOCUS ID | 3484 | ||||||||||
| GENE_SYMBOL | IGFBP1 | ||||||||||
| GENE NAME | insulin like growth | ||||||||||
| SYNONYMNS | AFBP, IBP1, PP12, IGF-BP25, hIGFBP-1 | ||||||||||
| CHROMOSOME | 7 | ||||||||||
| HOMOLOGENE ID | 498 |
| microRNAs | NA | NA |
| GENE SUMMARY |
|---|
| This gene is a member of the insulin-like growth factor binding protein (IGFBP) family and encodes a protein with an IGFBP domain and a thyroglobulin type-I domain. The protein binds both insulin-like growth factors (IGFs) I and II and circulates in the plasma. Binding of this protein prolongs the half-life of the IGFs and alters their interaction with cell surface receptors. [provided by RefSeq, Jul 2008] |
| OBSERVATIONS |
|---|
| Complication | Evidence | PMID |
| Nephropathy | 1. The first genomic markers to be associated with diabetic microvascular complications within the human IGFBP1 gene. | 16306374 |