| IGFBP3 |
| LOCUS ID | 3486 | ||||||||||
| GENE_SYMBOL | IGFBP3 | ||||||||||
| GENE NAME | insulin-like growth | ||||||||||
| SYNONYMNS | IBP3, BP-53 | ||||||||||
| CHROMOSOME | 7 | ||||||||||
| HOMOLOGENE ID | 510 |
| microRNAs | NA | NA |
| GENE SUMMARY |
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| This gene is a member of the insulin-like growth factor binding protein (IGFBP) family and encodes a protein with an IGFBP domain and a thyroglobulin type-I domain. The protein forms a terry complex with insulin-like growth factor acid-labile subunit (IGFALS) and either insulin-like growth factor (IGF) I or II. In this form, it circulates in the plasma, prolonging the half-life of IGFs and altering their interaction with cell surface receptors. Alterte transcriptional splice variants, encoding d |
| OBSERVATIONS |
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| Complication | Evidence | PMID |
| Nephropathy | 1. Insulin-like growth factor (IGF) and the insulin-like growth factor-binding protein-3 (IGFBP3) system are known to be involved in the development of experimental diabetic nephropathy, and Urinary IGFBP3 protease activity has been observed in patients with type 2 diabetes. | 22014109 |