| IGFBP7 |
| LOCUS ID | 3490 | ||||||||||
| GENE_SYMBOL | IGFBP7 | ||||||||||
| GENE NAME | insulin like growth | ||||||||||
| SYNONYMNS | AGM,PSF,TAF,FSTL2,IBP-7,MAC25,IGFBP-7,RAMSVPS,IGFBP-7v,IGFBPRP1 | ||||||||||
| CHROMOSOME | 4 | ||||||||||
| HOMOLOGENE ID | 1193 |
| microRNAs | NA | NA |
| GENE SUMMARY |
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| This gene encodes a member of the insulin-like growth factor (IGF)-binding protein (IGFBP) family. IGFBPs bind IGFs with high affinity, and regulate IGF availability in body fluids and tissues and modulate IGF binding to its receptors. This protein binds IGF-I and IGF-II with relatively low affinity, and belongs to a subfamily of low-affinity IGFBPs. It also stimulates prostacyclin production and cell adhesion. Alternatively spliced transcript variants encoding different isoforms have been descr |
| OBSERVATIONS |
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| Complication | Evidence | PMID |
| Nephropathy | TGF-beta1 enhances IGFBP7 via Smad2/4 pathways, and that IGFBP7 might be involved in the TGF-beta 1-induced tubular injury in DN | 26974954 |