IKBKB
LOCUS ID3551
GENE_SYMBOLIKBKB
GENE NAMEinhibitor of nuclear
SYNONYMNSIKK2 IKKB IMD15 NFKBIKB IKK-beta
CHROMOSOME8
HOMOLOGENE ID7782
microRNAsNANA
GENE SUMMARY
The protein encoded by this gene phosphorylates the inhibitor in the inhibitor/NF-kappa-B complex, causing dissociation of the inhibitor and activation of NF-kappa-B. The encoded protein itself is found in a complex of proteins. Several transcript variants, some protein-coding and some not, have been found for this gene. [provided by RefSeq, Sep 2011]

OBSERVATIONS

Complication Evidence PMID
Insulin resistance and inflammation1. MNCs from obese subjects have higher IKBKB expression, increased nuclear factor kappa B (NFkappaB) binding and higher mRNA expression of TNFAIP1 and IL6 genes. 17180352