| IKBKB |
| LOCUS ID | 3551 | ||||||||||
| GENE_SYMBOL | IKBKB | ||||||||||
| GENE NAME | inhibitor of nuclear | ||||||||||
| SYNONYMNS | IKK2 IKKB IMD15 NFKBIKB IKK-beta | ||||||||||
| CHROMOSOME | 8 | ||||||||||
| HOMOLOGENE ID | 7782 |
| microRNAs | NA | NA |
| GENE SUMMARY |
|---|
| The protein encoded by this gene phosphorylates the inhibitor in the inhibitor/NF-kappa-B complex, causing dissociation of the inhibitor and activation of NF-kappa-B. The encoded protein itself is found in a complex of proteins. Several transcript variants, some protein-coding and some not, have been found for this gene. [provided by RefSeq, Sep 2011] |
| OBSERVATIONS |
|---|
| Complication | Evidence | PMID |
| Insulin resistance and inflammation | 1. MNCs from obese subjects have higher IKBKB expression, increased nuclear factor kappa B (NFkappaB) binding and higher mRNA expression of TNFAIP1 and IL6 genes. | 17180352 |