IL10
LOCUS ID3586
GENE_SYMBOLIL10
GENE NAMEinterleukin 10
SYNONYMNSCSIF, TGIF, GVHDS, IL-10, IL10A
CHROMOSOME1
HOMOLOGENE ID478
microRNAsNANA
GENE SUMMARY
The protein encoded by this gene is a cytokine produced primarily by monocytes and to a lesser extent by lymphocytes. This cytokine has pleiotropic effects in immunoregulation and inflammation. It down-regulates the expression of Th1 cytokines, MHC class II Ags, and costimulatory molecules on macrophages. It also enhances B cell survival, proliferation, and antibody production. This cytokine can block NF-kappa B activity, and is involved in the regulation of the JAK-STAT signaling pathway. Knock

OBSERVATIONS

Complication Evidence PMID
Nephropathy1. IFNgamma and IL-10 were significantly elevated in patients with diabetic nephropathy (DN) and end-stage renal disease (ESRD) compared with controls and diabetic patients without DN.20187532
Neuropathy1. Our findings indicate that the tested markers within the IFNgamma and IL-10 genes, but not the TNFalpha gene, are significantly associated with peripheral neuropathy in South Indian type 2 diabetic patients. The study shows that the 'high-producer' IL-10 -1082 G/G genotype and the 'low-producer' IFNgamma +874 A/A genotype may be responsible for the down regulation of immune response leading to inflammation in this setting19608431
Tuberculosis1. Tuberculosis with diabetes is characterized by elevated circulating levels of type 1 (IFN-?, tumor necrosis factor-?, and IL-2), type 2 (IL-5), and type 17 (IL-17A) cytokines but decreased circulating levels of IL-22. This was associated with increased systemic levels of other pro-inflammatory cytokines (IL-1?, IL-6, and IL-18) and an anti-inflammatory cytokine (IL-10) but not type 1 IFNs.23987505
Cardiovascular1. Additionally, CAD-DM2 patients had significantly higher levels of plasma zonulin, TMAO, and IL-1B and significantly lower levels of IL-10 and FOXP3 mRNA expression than CAD-NDM2.29051757
Insulin resistance and inflammation1. Interestingly, these changes were accompanied with decreased expression levels of several inflammatory cytokines in adipose tissue, including TNF-?, IL6, IL10, IL1?, KC, MIP-1?, CD11b and CD14.22240021