| IL12B |
| LOCUS ID | 3593 | ||||||||||
| GENE_SYMBOL | IL12B | ||||||||||
| GENE NAME | interleukin 12B | ||||||||||
| SYNONYMNS | CLMF NKSF CLMF2 IMD28 IMD29 NKSF2 IL-12B | ||||||||||
| CHROMOSOME | 5 | ||||||||||
| HOMOLOGENE ID | 10400 |
| microRNAs | NA | NA |
| GENE SUMMARY |
|---|
| This gene encodes a subunit of interleukin 12, a cytokine that acts on T and natural killer cells, and has a broad array of biological activities. Interleukin 12 is a disulfide-linked heterodimer composed of the 40 kD cytokine receptor like subunit encoded by this gene, and a 35 kD subunit encoded by IL12A. This cytokine is expressed by activated macrophages that serve as an essential inducer of Th1 cells development. This cytokine has been found to be important for sustaining a sufficient numbe |
| OBSERVATIONS |
|---|
| Complication | Evidence | PMID |
| Psoriasis | 1. In our population, genetic variation at IL12B, IL23R and IL23A has an influence not only on the risk for Ps but also on disease severity and type 2 diabetes mellitus. | 24957500 |