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IL17A |
LOCUS ID | 3605 | ||||||||||||||||
GENE_SYMBOL | IL17A | ||||||||||||||||
GENE NAME | interleukin 17A | ||||||||||||||||
SYNONYMNS | IL17, CTLA8, IL-17, CTLA-8, IL-17A | ||||||||||||||||
CHROMOSOME | 6 | ||||||||||||||||
HOMOLOGENE ID | 1651 |
microRNAs | NA | NA |
GENE SUMMARY |
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The protein encoded by this gene is a proinflammatory cytokine produced by activated T cells. This cytokine regulates the activities of NF-kappaB and mitogen-activated protein kinases. This cytokine can stimulate the expression of IL6 and cyclooxygenase-2 (PTGS2/COX-2), as well as enhance the production of nitric oxide (NO). High levels of this cytokine are associated with several chronic inflammatory diseases including rheumatoid arthritis, psoriasis and multiple sclerosis. [provided by RefSeq, |
OBSERVATIONS |
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Complication | Evidence | PMID |
Nephropathy | 1. We observed that IL-17A levels in plasma and urine were reduced in patients with advanced diabetic nephropathy. | 26334030 |
Retinopathy | 1. Serum IL-6 and IL-17 were inversely associated with T2DM retinopathy. | 24632587 |
Tuberculosis | 1. We also found that TB-DM is characterized by expanded frequencies of TB antigen-stimulated NK cells expressing type 1 (tumour necrosis factor-?) and type 17 (IL-17A and IL-17F) cytokines | 25363329 |