| IL1R1 |
| LOCUS ID | 3554 | ||||||||||
| GENE_SYMBOL | IL1R1 | ||||||||||
| GENE NAME | interleukin 1 recept | ||||||||||
| SYNONYMNS | P80 IL1R IL1RA CD121A D2S1473 IL-1R-alpha | ||||||||||
| CHROMOSOME | 2 | ||||||||||
| HOMOLOGENE ID | 677 |
| microRNAs | NA | NA |
| GENE SUMMARY |
|---|
| This gene encodes a cytokine receptor that belongs to the interleukin-1 receptor family. The encoded protein is a receptor for interleukin-1 alpha, interleukin-1 beta, and interleukin-1 receptor antagonist. It is an important mediator involved in many cytokine-induced immune and inflammatory responses. This gene is located in a cluster of related cytokine receptor genes on chromosome 2q12. [provided by RefSeq, Dec 2013] |
| OBSERVATIONS |
|---|
| Complication | Evidence | PMID |
| Insulin resistance and inflammation | 1. ?the DNA methylation status of the CpG sites cg18773937 and cg23149881 in?IL-1? ?gene and the CpG site cg13399261 in?IL1R1?gene could serve as an epigenetic marker of chronic inflammation and T2D development. | 31476928 |