| IL1RN |
| LOCUS ID | 3557 | |||||||||||||
| GENE_SYMBOL | IL1RN | |||||||||||||
| GENE NAME | interleukin 1 recept | |||||||||||||
| SYNONYMNS | DIRA, IRAP, IL1F3, IL1RA, MVCD4, IL-1RN, IL-1ra, I | |||||||||||||
| CHROMOSOME | 2 | |||||||||||||
| HOMOLOGENE ID | 11163 |
| microRNAs | NA | NA |
| GENE SUMMARY |
|---|
| This gene encodes a member of the class II cytokine receptor family. The encoded soluble protein specifically binds to and inhibits interleukin 22 activity by blocking the interaction of interleukin 22 with its cell surface receptor. The encoded protein may be important in the regulation of inflammatory response, and has been implicated in the regulation of tumorigenesis in the colon. Altertive splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Jul |
| OBSERVATIONS |
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| Complication | Evidence | PMID |
| Nephropathy | 1. IL1B2 and IL1RN*2 genotypes of the IL-1 cluster genes are associated with diabetic nephropathy in Korean patients with type 2 DM. | 15286433 |
| Insulin resistance and inflammation | 1. We found clear evidence that signals for IL-1?, IL1RN, TNF-? and TGF?-1 are present in both adipose and liver tissues and that these are linked to the development of inflammation and insulin resistance in the HFC-fed mice. | 21410952 |