| IL20 |
| LOCUS ID | 50604 | ||||||||||
| GENE_SYMBOL | IL20 | ||||||||||
| GENE NAME | interleukin 20 | ||||||||||
| SYNONYMNS | IL-20, IL10D, ZCYTO10 | ||||||||||
| CHROMOSOME | 1 | ||||||||||
| HOMOLOGENE ID | 10286 |
| microRNAs | NA | NA |
| GENE SUMMARY |
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| The protein encoded by this gene is a cytokine structurally related to interleukin 10 (IL10). This cytokine has been shown to transduce its signal through signal transducer and activator of transcription 3 (STAT3) in keratinocytes. A specific receptor for this cytokine is found to be expressed in skin and upregulated dramatically in psoriatic skin, suggesting a role for this protein in epidermal function and psoriasis. [provided by RefSeq, Jul 2008] |
| OBSERVATIONS |
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| Complication | Evidence | PMID |
| Tuberculosis | 1. Our data reveal that coincident diabetes in either PTB or LTB is characterized by decreased production of the IL-20 subfamily of cytokines and suggest that these cytokines might play an important role in pathogenesis or protection | 26354610 |