| IL21 |
| LOCUS ID | 59067 | ||||||||||
| GENE_SYMBOL | IL21 | ||||||||||
| GENE NAME | interleukin 21 | ||||||||||
| SYNONYMNS | Za11 IL-21 CVID11 | ||||||||||
| CHROMOSOME | 4 | ||||||||||
| HOMOLOGENE ID | 11032 |
| microRNAs | NA | NA |
| GENE SUMMARY |
|---|
| This gene encodes a member of the common-gamma chain family of cytokines with immunoregulatory activity. The encoded protein plays a role in both the innate and adaptive immune responses by inducing the differentiation, proliferation and activity of multiple target cells including macrophages, natural killer cells, B cells and cytotoxic T cells. Dysregulation of this gene plays a role in multiple immune-mediated diseases including lupus, psoriasis and chronic inflammatory diseases. Alternatively |
| OBSERVATIONS |
|---|
| Complication | Evidence | PMID |
| Insulin resistance and inflammation | 1. Since interleukin (IL)-21 plays an important role in inducing and maintaining immune-mediated chronic inflammatory processes and negatively regulates Treg differentiation/activity, | 24430438 |