| IL23R |
| LOCUS ID | 149233 | ||||||||||
| GENE_SYMBOL | IL23R | ||||||||||
| GENE NAME | interleukin 23 recep | ||||||||||
| SYNONYMNS | |||||||||||
| CHROMOSOME | 1 | ||||||||||
| HOMOLOGENE ID | 87555 |
| microRNAs | NA | NA |
| GENE SUMMARY |
|---|
| The protein encoded by this gene is a subunit of the receptor for IL23A/IL23. This protein pairs with the receptor molecule IL12RB1/IL12Rbeta1, and both are required for IL23A signaling. This protein associates constitutively with Janus kinase 2 (JAK2), and also binds to transcription activator STAT3 in a ligand-dependent manner. |
| OBSERVATIONS |
|---|
| Complication | Evidence | PMID |
| Psoriasis | 1. In our population, genetic variation at IL12B, IL23R and IL23A has an influence not only on the risk for Ps but also on disease severity and type 2 diabetes mellitus. | 24957500 |