| IL31 |
| LOCUS ID | 386653 | ||||||||||
| GENE_SYMBOL | IL31 | ||||||||||
| GENE NAME | interleukin 31 | ||||||||||
| SYNONYMNS | IL-31 | ||||||||||
| CHROMOSOME | 12 | ||||||||||
| HOMOLOGENE ID | 88541 |
| microRNAs | NA | NA |
| GENE SUMMARY |
|---|
| IL31, which is made principally by activated Th2-type T cells, interacts with a heterodimeric receptor consisting of IL31RA (MIM 609510) and OSMR (MIM 601743) that is constitutively expressed on epithelial cells and keratinocytes. IL31 may be involved in the promotion of allergic skin disorders and in regulating other allergic diseases, such as asthma (Dillon et al., 2004 [PubMed 15184896]).[supplied by OMIM, Mar 2008] |
| OBSERVATIONS |
|---|
| Complication | Evidence | PMID |
| Retinopathy | 1. In PDR patients, vitreous IL-17A level correlated significantly with vitreous levels of IL-22 and IL-31, and especially with IL-4 and TNF alpha. | 26352837 |