| IL32 |
| LOCUS ID | 9235 | ||||||||||
| GENE_SYMBOL | IL32 | ||||||||||
| GENE NAME | interleukin 32 | ||||||||||
| SYNONYMNS | NK4 TAIF TAIFa TAIFb TAIFc TAIFd IL-32beta IL-32alpha IL-32delta IL-32gamma | ||||||||||
| CHROMOSOME | 16 | ||||||||||
| HOMOLOGENE ID | 128400 |
| microRNAs | NA | NA |
| GENE SUMMARY |
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| This gene encodes a member of the cytokine family. The protein contains a tyrosine sulfation site, 3 potential N-myristoylation sites, multiple putative phosphorylation sites, and an RGD cell-attachment sequence. Expression of this protein is increased after the activation of T-cells by mitogens or the activation of NK cells by IL-2. This protein induces the production of TNFalpha from macrophage cells. Alternate transcriptional splice variants, encoding different isoforms, have been characteriz |
| OBSERVATIONS |
|---|
| Complication | Evidence | PMID |
| Insulin resistance and inflammation | 1. IL32, which is the major deregulated gene, correlated with body mass index (BMI), waist circumference, NAFLD activity score (NAS), aminotransferases (alanine aminotransferase [ALAT] and aspartate aminotransferase [ASAT]), and homeostasis model assessment of insulin resistance (HOMA-IR) index in patients. | 31497742 |