| IL5 |
| LOCUS ID | 3567 | ||||||||||
| GENE_SYMBOL | IL5 | ||||||||||
| GENE NAME | interleukin 5 | ||||||||||
| SYNONYMNS | EDF, TRF, IL-5 | ||||||||||
| CHROMOSOME | 5 | ||||||||||
| HOMOLOGENE ID | 679 |
| microRNAs | NA | NA |
| GENE SUMMARY |
|---|
| This gene encodes a cytokine that acts as a growth and differentiation factor for both B cells and eosinophils. The encoded cytokine plays a major role in the regulation of eosinophil formation, maturation, recruitment and survival. The increased production of this cytokine may be related to pathogenesis of eosinophil-dependent inflammatory diseases. This cytokine functions by binding to its receptor, which is a heterodimer, whose beta subunit is shared with the receptors for interleukine 3 (IL3 |
| OBSERVATIONS |
|---|
| Complication | Evidence | PMID |
| Tuberculosis | 1. Tuberculosis with diabetes is characterized by elevated circulating levels of type 1 (IFN-?, tumor necrosis factor-?, and IL-2), type 2 (IL-5), and type 17 (IL-17A) cytokines but decreased circulating levels of IL-22. This was associated with increased systemic levels of other pro-inflammatory cytokines (IL-1?, IL-6, and IL-18) and an anti-inflammatory cytokine (IL-10) but not type 1 IFNs. | 23987505 |