| IL6R |
| LOCUS ID | 3570 | ||||||||||
| GENE_SYMBOL | IL6R | ||||||||||
| GENE NAME | interleukin 6 recept | ||||||||||
| SYNONYMNS | IL6Q,gp80,CD126,IL6RA,IL6RQ,IL-6RA,IL-6R-1 | ||||||||||
| CHROMOSOME | 1 | ||||||||||
| HOMOLOGENE ID | 474 |
| microRNAs | NA | NA |
| GENE SUMMARY |
|---|
| This gene encodes a subunit of the interleukin 6 (IL6) receptor complex. Interleukin 6 is a potent pleiotropic cytokine that regulates cell growth and differentiation and plays an important role in the immune response. The IL6 receptor is a protein complex consisting of this protein and interleukin 6 signal transducer (IL6ST/GP130/IL6-beta), a receptor subunit also shared by many other cytokines. Dysregulated production of IL6 and this receptor are implicated in the pathogenesis of many diseases |
| OBSERVATIONS |
|---|
| Complication | Evidence | PMID |
| Atherosclerosis | 1. Using network analysis, we have identified several cellular network proteins like PTPN1, AKT1, INSR, LEPR, IRS1, IRS2, IL1R2, IL6R, PCSK9 and MYD88, which are responsible for regulating inflammation, insulin resistance, and atherosclerosis. We have identified three distinct sets of serum markers for diabetes, CAD and diabetes associated with CAD in Indian patients using nonparametric-based machine learning approach. These multiple marker classifiers may be useful for monitoring progression from a healthy person to T2DM and T2DM to T2DM_CAD. | 30674322 |