| IRAK1 |
| LOCUS ID | 3654 | |||||||||||||
| GENE_SYMBOL | IRAK1 | |||||||||||||
| GENE NAME | interleukin 1 recept | |||||||||||||
| SYNONYMNS | IRAK, pelle | |||||||||||||
| CHROMOSOME | X | |||||||||||||
| HOMOLOGENE ID | 37496 |
| microRNAs | NA | NA |
| GENE SUMMARY |
|---|
| This gene encodes the interleukin-1 receptor-associated kinase 1, one of two putative serine/threonine kinases that become associated with the interleukin-1 receptor (IL1R) upon stimulation. This gene is partially responsible for IL1-induced upregulation of the transcription factor NF-kappa B. Altertively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008] |
| OBSERVATIONS |
|---|
| Complication | Evidence | PMID |
| Neuropathy | 1. Treatment of diabetic peripheral neuropathy with sildefil, a phosphodiesterase type 5 inhibitor, augmentedMiRNA-146a expression and decreased levels of IRAK1 and TRAF6 in the DRG neurons. In vitro, blockage ofMiRNA-146a in DRG neurons abolished the effect of sildefil on DRG neuron protection and downregulation of IRAK1 and TRAF6 proteins under hyperglycemia. Our data provide the first evidence showing thatMiRNA-146a plays an important role in mediating DRG neuron apoptosis under hyperglycemic conditions. | 24316060 |
| Insulin resistance and inflammation | 1. Interestingly, the levels of interleukin-1 receptor-associated kinase 1 (IRAK1) and the activity of nucleus factor-kappaB (NF-kappaB) were also significantly increased. | 19717152 |