| IRAK3 |
| LOCUS ID | 11213 | ||||||||||
| GENE_SYMBOL | IRAK3 | ||||||||||
| GENE NAME | interleukin 1 recept | ||||||||||
| SYNONYMNS | ASRT5 IRAKM | ||||||||||
| CHROMOSOME | 12 | ||||||||||
| HOMOLOGENE ID | 36215 |
| microRNAs | NA | NA |
| GENE SUMMARY |
|---|
| This gene encodes a member of the interleukin-1 receptor-associated kinase protein family. Members of this family are essential components of the Toll/IL-R immune signal transduction pathways. This protein is primarily expressed in monocytes and macrophages and functions as a negative regulator of Toll-like receptor signaling. Mutations in this gene are associated with a susceptibility to asthma. Alternate splicing results in multiple transcript variants. [provided by RefSeq, May 2010] |
| OBSERVATIONS |
|---|
| Complication | Evidence | PMID |
| Insulin resistance and inflammation | 1. Interleukin-1 receptor-associated kinase-3 (IRAK3), key inhibitor of IRAK/NF?B-mediated chronic inflammation, is downregulated in monocytes of obese persons. | 22272346 |