IRAK3
LOCUS ID11213
GENE_SYMBOLIRAK3
GENE NAMEinterleukin 1 recept
SYNONYMNSASRT5 IRAKM
CHROMOSOME12
HOMOLOGENE ID36215
microRNAsNANA
GENE SUMMARY
This gene encodes a member of the interleukin-1 receptor-associated kinase protein family. Members of this family are essential components of the Toll/IL-R immune signal transduction pathways. This protein is primarily expressed in monocytes and macrophages and functions as a negative regulator of Toll-like receptor signaling. Mutations in this gene are associated with a susceptibility to asthma. Alternate splicing results in multiple transcript variants. [provided by RefSeq, May 2010]

OBSERVATIONS

Complication Evidence PMID
Insulin resistance and inflammation1. Interleukin-1 receptor-associated kinase-3 (IRAK3), key inhibitor of IRAK/NF?B-mediated chronic inflammation, is downregulated in monocytes of obese persons.22272346