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IRAK3 |
LOCUS ID | 11213 | ||||||||||
GENE_SYMBOL | IRAK3 | ||||||||||
GENE NAME | interleukin 1 recept | ||||||||||
SYNONYMNS | ASRT5 IRAKM | ||||||||||
CHROMOSOME | 12 | ||||||||||
HOMOLOGENE ID | 36215 |
microRNAs | NA | NA |
GENE SUMMARY |
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This gene encodes a member of the interleukin-1 receptor-associated kinase protein family. Members of this family are essential components of the Toll/IL-R immune signal transduction pathways. This protein is primarily expressed in monocytes and macrophages and functions as a negative regulator of Toll-like receptor signaling. Mutations in this gene are associated with a susceptibility to asthma. Alternate splicing results in multiple transcript variants. [provided by RefSeq, May 2010] |
OBSERVATIONS |
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Complication | Evidence | PMID |
Insulin resistance and inflammation | 1. Interleukin-1 receptor-associated kinase-3 (IRAK3), key inhibitor of IRAK/NF?B-mediated chronic inflammation, is downregulated in monocytes of obese persons. | 22272346 |