| IRF1 |
| LOCUS ID | 3659 | ||||||||||
| GENE_SYMBOL | IRF1 | ||||||||||
| GENE NAME | interferon regulator | ||||||||||
| SYNONYMNS | MAR IRF-1 | ||||||||||
| CHROMOSOME | 5 | ||||||||||
| HOMOLOGENE ID | 1658 |
| microRNAs | NA | NA |
| GENE SUMMARY |
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| The protein encoded by this gene is a transcriptional regulator and tumor suppressor, serving as an activator of genes involved in both innate and acquired immune responses. The encoded protein activates the transcription of genes involved in the body's response to viruses and bacteria, playing a role in cell proliferation, apoptosis, the immune response, and DNA damage response. This protein represses the transcription of several other genes. As a tumor suppressor, it both suppresses tumor |
| OBSERVATIONS |
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| Complication | Evidence | PMID |
| Insulin resistance and inflammation | 1. Oxidized LDL correlated positively with the expression of IRF1 and TLR2 suggesting a relation between oxidative stress and inflammation in coronary atherosclerotic plaques. | 18669160 |