| IRF3 |
| LOCUS ID | 3661 | ||||||||||
| GENE_SYMBOL | IRF3 | ||||||||||
| GENE NAME | interferon regulator | ||||||||||
| SYNONYMNS | IIAE7 | ||||||||||
| CHROMOSOME | 19 | ||||||||||
| HOMOLOGENE ID | 1208 |
| microRNAs | NA | NA |
| GENE SUMMARY |
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| This gene encodes a member of the interferon regulatory transcription factor (IRF) family. The encoded protein is found in an inactive cytoplasmic form that upon serine/threonine phosphorylation forms a complex with CREBBP. This complex translocates to the nucleus and activates the transcription of interferons alpha and beta, as well as other interferon-induced genes. The protein plays an important role in the innate immune response against DNA and RNA viruses. Mutations in this gene are associa |
| OBSERVATIONS |
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| Complication | Evidence | PMID |
| Insulin resistance and inflammation | 1. The global knockout (KO) of IRF3 significantly promotes chronic high-fat diet (HFD)-induced hepatic insulin resistance and steatosis; in contrast, adenoviral-mediated hepatic IRF3 overexpression preserves glucose and lipid homeostasis. | 24123166 |