| IRF4 |
| LOCUS ID | 3662 | ||||||||||
| GENE_SYMBOL | IRF4 | ||||||||||
| GENE NAME | interferon regulator | ||||||||||
| SYNONYMNS | MUM1 LSIRF SHEP8 NF-EM5 | ||||||||||
| CHROMOSOME | 6 | ||||||||||
| HOMOLOGENE ID | 1842 |
| microRNAs | NA | NA |
| GENE SUMMARY |
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| The protein encoded by this gene belongs to the IRF (interferon regulatory factor) family of transcription factors, characterized by an unique tryptophan pentad repeat DNA-binding domain. The IRFs are important in the regulation of interferons in response to infection by virus, and in the regulation of interferon-inducible genes. This family member is lymphocyte specific and negatively regulates Toll-like-receptor (TLR) signaling that is central to the activation of innate and adaptive immune sy |
| OBSERVATIONS |
|---|
| Complication | Evidence | PMID |
| Insulin resistance and inflammation | 1. IRF4 expression is regulated in primary macrophages and in ATMs of high-fat diet-induced obese mice. Irf4(-/-) macrophages produce higher levels of proinflammatory cytokines, including interleukin-1? and tumor necrosis factor-?, in response to fatty acids. | 23835343 |