| IRF9 |
| LOCUS ID | 10379 | ||||||||||
| GENE_SYMBOL | IRF9 | ||||||||||
| GENE NAME | interferon regulator | ||||||||||
| SYNONYMNS | p48 IRF-9 ISGF3 ISGF3G | ||||||||||
| CHROMOSOME | 14 | ||||||||||
| HOMOLOGENE ID | 4436 |
| microRNAs | NA | NA |
| GENE SUMMARY |
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| This gene encodes a member of the interferon regulatory factor (IRF) family, a group of transcription factors with diverse roles, including virus-mediated activation of interferon, and modulation of cell growth, differentiation, apoptosis, and immune system activity. Members of the IRF family are characterized by a conserved N-terminal DNA-binding domain containing tryptophan (W) repeats. Mutations in this gene result in Immunodeficiency 65. [provided by RefSeq, Jul 2020] |
| OBSERVATIONS |
|---|
| Complication | Evidence | PMID |
| Insulin resistance and inflammation | 1. whole-body IRF9 knockout (KO) mice were more obese and had aggravated IR, hepatic steatosis, and inflammation after chronic high-fat diet feeding. | 23471885 |