| IRS1 |
| LOCUS ID | 3667 | ||||||||||||||||
| GENE_SYMBOL | IRS1 | ||||||||||||||||
| GENE NAME | insulin receptor sub | ||||||||||||||||
| SYNONYMNS | HIRS-1 | ||||||||||||||||
| CHROMOSOME | 2 | ||||||||||||||||
| HOMOLOGENE ID | 4049 |
| microRNAs | miR-144 | 24497980 |
| GENE SUMMARY |
|---|
| This gene encodes a protein which is phosphorylated by insulin receptor tyrosine kinase. Mutations in this gene are associated with type II diabetes and susceptibility to insulin resistance. [provided by RefSeq, Nov 2009] |
| OBSERVATIONS |
|---|
| Complication | Evidence | PMID |
| Retinopathy | 1. The goal of this present study was to investigate a potential mechanism for retinal endothelial cell apoptosis in response to hyperglycemia.Increased TNF-alpha inhibits insulin signaling in 2 ways1) increased phosphorylation of IRS-1(Ser307), 2) increased SOCS3 levels to decrease total IRS-1 and increase IR(Tyr960), both of which block normal insulin signal transduction. | 22266116 |
| Atherosclerosis | 1. Using network analysis, we have identified several cellular network proteins like PTPN1, AKT1, INSR, LEPR, IRS1, IRS2, IL1R2, IL6R, PCSK9 and MYD88, which are responsible for regulating inflammation, insulin resistance, and atherosclerosis. We have identified three distinct sets of serum markers for diabetes, CAD and diabetes associated with CAD in Indian patients using nonparametric-based machine learning approach. These multiple marker classifiers may be useful for monitoring progression from a healthy person to T2DM and T2DM to T2DM_CAD. | 30674322 |
| Insulin resistance and inflammation | 1. Adenoviral-mediated expression of SOCS1 in mouse liver dramatically reduced hepatic IRS1 and IRS2 protein levels and caused glucose intolerance; by contrast, expression of the SOCS1 mutants had no effect. | 12228220 |