| ITGA2 |
| LOCUS ID | 3673 | ||||||||||
| GENE_SYMBOL | ITGA2 | ||||||||||
| GENE NAME | integrin subunit alp | ||||||||||
| SYNONYMNS | BR, GPIa, CD49B, HPA-5, VLA-2, VLAA2 | ||||||||||
| CHROMOSOME | 5 | ||||||||||
| HOMOLOGENE ID | 1662 |
| microRNAs | NA | NA |
| GENE SUMMARY |
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| This gene encodes the alpha subunit of a transmembrane receptor for collagens and related proteins. The encoded protein forms a heterodimer with a beta subunit and mediates the adhesion of platelets and other cell types to the extracellular matrix. Loss of the encoded protein is associated with bleeding disorder platelet-type 9. Antibodies against this protein are found in several immune disorders, including neotal alloimmune thrombocytopenia. This gene is located adjacent to a related alpha sub |
| OBSERVATIONS |
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| Complication | Evidence | PMID |
| Retinopathy | 1. A significant association between the G894T polymorphism of eNOS and BgI II polymorphism of ITGA2 genes and DR was observed | 23776381 |