| ITGAM |
| LOCUS ID | 3684 | |||||||||||||
| GENE_SYMBOL | ITGAM | |||||||||||||
| GENE NAME | integrin, alpha M (c | |||||||||||||
| SYNONYMNS | CR3A, MO1A, CD11B, MAC-1, MAC1A, SLEB6 | |||||||||||||
| CHROMOSOME | 16 | |||||||||||||
| HOMOLOGENE ID | 526 |
| microRNAs | NA | NA |
| GENE SUMMARY |
|---|
| This gene encodes the integrin alpha M chain. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain. This I-domain containing alpha integrin combines with the beta 2 chain (ITGB2) to form a leukocyte-specific integrin referred to as macrophage receptor 1 ('Mac-1'), or inactivated-C3b (iC3b) receptor 3 ('CR3'). The alpha M beta 2 integrin is important in the adherence of neutrophils and monocytes to stimulated endothelium, and also |
| OBSERVATIONS |
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| Complication | Evidence | PMID |
| Nephropathy | 1. The expression of the CD11b antigen on the surface of the polymorphonuclear leukocytes is increased in patients with early diabetic nephropathy (microangiopathy) and diabetic patients before development vascular complications, suggesting the presence of an increased inflammatory response in these individuals. | 16617732 |
| Retinopathy | 1. We conclude that antagonism of CD11b (integrin alphambeta2) by NIF is sufficient to inhibit early stages of diabetic retinopathy, while not compromising the basic immune response. | 24205223 |