| ITGAX |
| LOCUS ID | 3687 | ||||||||||
| GENE_SYMBOL | ITGAX | ||||||||||
| GENE NAME | integrin subunit alp | ||||||||||
| SYNONYMNS | CD11C SLEB6 | ||||||||||
| CHROMOSOME | 16 | ||||||||||
| HOMOLOGENE ID | 55493 |
| microRNAs | NA | NA |
| GENE SUMMARY |
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| This gene encodes the integrin alpha X chain protein. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain. This protein combines with the beta 2 chain (ITGB2) to form a leukocyte-specific integrin referred to as inactivated-C3b (iC3b) receptor 4 (CR4). The alpha X beta 2 complex seems to overlap the properties of the alpha M beta 2 integrin in the adherence of neutrophils and monocytes to stimulated endothelium cells, and in the phagocytosis of comp |
| OBSERVATIONS |
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| Complication | Evidence | PMID |
| Insulin resistance and inflammation | 1. Obese C57BL/6 mice had increased CD11c (ITGAX) in AT and blood compared with lean controls. | 19910635 |