| ITGB3 |
| LOCUS ID | 3690 | ||||||||||
| GENE_SYMBOL | ITGB3 | ||||||||||
| GENE NAME | integrin, beta 3 (pl | ||||||||||
| SYNONYMNS | GT, CD61, GP3A, BDPLT2, GPIIIa, BDPLT16 | ||||||||||
| CHROMOSOME | 17 | ||||||||||
| HOMOLOGENE ID | 55444 |
| microRNAs | NA | NA |
| GENE SUMMARY |
|---|
| The ITGB3 protein product is the integrin beta chain beta 3. Integrins are integral cell-surface proteins composed of an alpha chain and a beta chain. A given chain may combine with multiple partners resulting in different integrins. Integrin beta 3 is found along with the alpha IIb chain in platelets. Integrins are known to participate in cell adhesion as well as cell-surface mediated siglling. [provided by RefSeq, Jul 2008] |
| OBSERVATIONS |
|---|
| Complication | Evidence | PMID |
| Retinopathy | 1. Genetic polymorphisms of the alpha2beta1 integrin and glycoprotein IIIa (GPIIIa) have been associated with myocardial infarction, stroke, and diabetic retinopathy. | 11728949 |