| JUN |
| LOCUS ID | 3725 | ||||||||||
| GENE_SYMBOL | JUN | ||||||||||
| GENE NAME | Jun proto-oncogene, | ||||||||||
| SYNONYMNS | AP1 p39 AP-1 cJUN c-Jun | ||||||||||
| CHROMOSOME | 1 | ||||||||||
| HOMOLOGENE ID | 1679 |
| microRNAs | NA | NA |
| GENE SUMMARY |
|---|
| This gene is the putative transforming gene of avian sarcoma virus 17. It encodes a protein which is highly similar to the viral protein, and which interacts directly with specific target DNA sequences to regulate gene expression. This gene is intronless and is mapped to 1p32-p31, a chromosomal region involved in both translocations and deletions in human malignancies. [provided by RefSeq, Jul 2008] |
| OBSERVATIONS |
|---|
| Complication | Evidence | PMID |
| Insulin resistance and inflammation | 1. Adipose tissue from Nmf15 mice showed a remarkable degree of inflammation and macrophage infiltration as indicated by expression of the F4/80 marker and increased phosphorylation of JUN N-terminal kinase 1/2. | 19398498 |