| KCNJ8 |
| LOCUS ID | 3764 | ||||||||||
| GENE_SYMBOL | KCNJ8 | ||||||||||
| GENE NAME | potassium inwardly r | ||||||||||
| SYNONYMNS | KIR6.1 uKATP-1 | ||||||||||
| CHROMOSOME | 12 | ||||||||||
| HOMOLOGENE ID | 3654 |
| microRNAs | NA | NA |
| GENE SUMMARY |
|---|
| Potassium channels are present in most mammalian cells, where they participate in a wide range of physiologic responses. The protein encoded by this gene is an integral membrane protein and inward-rectifier type potassium channel. The encoded protein, which has a greater tendency to allow potassium to flow into a cell rather than out of a cell, is controlled by G-proteins. Defects in this gene may be a cause of J-wave syndromes and sudden infant death syndrome (SIDS). [provided by RefSeq, May 20 |
| OBSERVATIONS |
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| Complication | Evidence | PMID |
| Insulin resistance and inflammation | 1. Our results reveal a previously unrecognized function of Kir6.1 as a negative regulator of the NLRP3 inflammasome and insulin resistance, which is mediated by virtue of its ability to inhibit NLRP3 inflammasome assembly.? | 31387986 |