| KDM1A |
| LOCUS ID | 23028 | ||||||||||
| GENE_SYMBOL | KDM1A | ||||||||||
| GENE NAME | lysine demethylase 1 | ||||||||||
| SYNONYMNS | AOF2, CPRF, KDM1, LSD1, BHC110 | ||||||||||
| CHROMOSOME | 1 | ||||||||||
| HOMOLOGENE ID | 32240 |
| microRNAs | NA | NA |
| GENE SUMMARY |
|---|
| This gene encodes a nuclear protein containing a SWIRM domain, a FAD-binding motif, and an amine oxidase domain. This protein is a component of several histone deacetylase complexes, though it silences genes by functioning as a histone demethylase. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2009] |
| OBSERVATIONS |
|---|
| Complication | Evidence | PMID |
| Retinopathy | 1. Thus, the regulation of LSD1 by molecular or pharmacological means has the potential to retard the development of diabetic retinopathy. | 23423566 |