| KLF10 |
| LOCUS ID | 7071 | ||||||||||
| GENE_SYMBOL | KLF10 | ||||||||||
| GENE NAME | Kruppel-like factor | ||||||||||
| SYNONYMNS | EGRA, TIEG, TIEG1, EGR-alpha | ||||||||||
| CHROMOSOME | 8 | ||||||||||
| HOMOLOGENE ID | 4135 |
| microRNAs | NA | NA |
| GENE SUMMARY |
|---|
| This gene encodes a member of a family of proteins that feature C2H2-type zinc finger domains. The encoded protein is a transcriptional repressor that acts as an effector of transforming growth factor beta sigling. Activity of this protein may inhibit the growth of cancers, particularly pancreatic cancer. Altertive splicing results in multiple transcript variants. [provided by RefSeq, Jun 2013] |
| OBSERVATIONS |
|---|
| Complication | Evidence | PMID |
| Nephropathy | 1. TIEG-siR may be useful in preventing the progression of diabetic nephropathy through influencing the expression of Smad2 and its activation and down-regulating collagen IV. | 20979836 |