| KLF4 |
| LOCUS ID | 9314 | ||||||||||
| GENE_SYMBOL | KLF4 | ||||||||||
| GENE NAME | Kruppel like factor | ||||||||||
| SYNONYMNS | EZF GKLF | ||||||||||
| CHROMOSOME | 9 | ||||||||||
| HOMOLOGENE ID | 3123 |
| microRNAs | NA | NA |
| GENE SUMMARY |
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| This gene encodes a protein that belongs to the Kruppel family of transcription factors. The encoded zinc finger protein is required for normal development of the barrier function of skin. The encoded protein is thought to control the G1-to-S transition of the cell cycle following DNA damage by mediating the tumor suppressor gene p53. Mice lacking this gene have a normal appearance but lose weight rapidly, and die shortly after birth due to fluid evaporation resulting from compromised epidermal |
| OBSERVATIONS |
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| Complication | Evidence | PMID |
| Insulin resistance and inflammation | 1. Macrophage KLF4 expression was robustly induced in M2 macrophages and strongly reduced in M1 macrophages, observations that were recapitulated in human inflammatory paradigms in vivo. | 21670502 |