| KLF6 |
| LOCUS ID | 1316 | |||||||||||||
| GENE_SYMBOL | KLF6 | |||||||||||||
| GENE NAME | Kruppel-like factor | |||||||||||||
| SYNONYMNS | GBF, ZF9, BCD1, CBA1, CPBP, PAC1, ST12, COPEB | |||||||||||||
| CHROMOSOME | 10 | |||||||||||||
| HOMOLOGENE ID | 996 |
| microRNAs | NA | NA |
| GENE SUMMARY |
|---|
| This gene encodes a member of the Kruppel-like family of transcription factors. The zinc finger protein is a transcriptional activator, and functions as a tumor suppressor. Multiple transcript variants encoding different isoforms have been found for this gene, some of which are implicated in carcinogenesis. [provided by RefSeq, May 2009] |
| OBSERVATIONS |
|---|
| Complication | Evidence | PMID |
| Nephropathy | 1. KLF6 overexpression increased MIP-3alpha which was inhibited by concurrent exposure to PPAR-gamma agonists. PPAR-gamma agonists attenuated high glucose-induced MIP-3alpha secretion.The recognition of MIP-3alpha as a significant pathogenic mediator in diabetic nephropathy reaffirms the increasingly recognized role of inflammation in the progression of DN | 21109018 |
| Insulin resistance and inflammation | 1. myeloid-Klf6?deficiency significantly curbs diet-induced adipose tissue inflammation, obesity, glucose intolerance, and insulin resistance. | 31262200 |