| KRAS |
| LOCUS ID | 3845 | ||||||||||
| GENE_SYMBOL | KRAS | ||||||||||
| GENE NAME | KRAS proto-oncogene, | ||||||||||
| SYNONYMNS | NS NS3 OES CFC2 RALD K-Ras KRAS1 KRAS2 RASK2 KI-RAS C-K-RAS K-RAS2A K-RAS2B K-RAS4A K-RAS4B K-Ras 2 | ||||||||||
| CHROMOSOME | 12 | ||||||||||
| HOMOLOGENE ID | 37990 |
| microRNAs | NA | NA |
| GENE SUMMARY |
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| This gene, a Kirsten ras oncogene homolog from the mammalian ras gene family, encodes a protein that is a member of the small GTPase superfamily. A single amino acid substitution is responsible for an activating mutation. The transforming protein that results is implicated in various malignancies, including lung adenocarcinoma, mucinous adenoma, ductal carcinoma of the pancreas and colorectal carcinoma. Alternative splicing leads to variants encoding two isoforms that differ in the C-terminal re |
| OBSERVATIONS |
|---|
| Complication | Evidence | PMID |
| Insulin resistance and inflammation | 1. Multiple factors "upstream" of KRAS associated with obesity, including insulin resistance, inflammation, changes in gut microbiota and GI peptides, can enhance/modulate downstream signa | 29079305 |