| LAMC1 |
| LOCUS ID | 3915 | ||||||||||
| GENE_SYMBOL | LAMC1 | ||||||||||
| GENE NAME | laminin subunit gamm | ||||||||||
| SYNONYMNS | LAMB2 | ||||||||||
| CHROMOSOME | 1 | ||||||||||
| HOMOLOGENE ID | 1724 |
| microRNAs | NA | NA |
| GENE SUMMARY |
|---|
| Laminins, a family of extracellular matrix glycoproteins, are the major noncollagenous constituent of basement membranes. They have been implicated in a wide variety of biological processes including cell adhesion, differentiation, migration, sigling, neurite outgrowth and metastasis. Laminins, composed of 3 non identical chainslaminin alpha, beta and gamma (formerly A, B1, and B2, respectively), have a cruciform structure consisting of 3 short arms, each formed by a different chain, and a long |
| OBSERVATIONS |
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| Complication | Evidence | PMID |
| Nephropathy | 1. Elevated concentrations of glucose increase let-7b, which reduces HMGA2 expression, in turn reducing IMP2 and LAMB2. Correlative changes in kidney tissues from control and streptozotocin-induced diabetic rats suggest these control mechanisms are operative in vivo and may contribute to proteinuria in diabetic nephropathy | 22513850 |