| LBP |
| LOCUS ID | 3929 | ||||||||||
| GENE_SYMBOL | LBP | ||||||||||
| GENE NAME | lipopolysaccharide b | ||||||||||
| SYNONYMNS | BPIFD2 | ||||||||||
| CHROMOSOME | 20 | ||||||||||
| HOMOLOGENE ID | 3055 |
| microRNAs | NA | NA |
| GENE SUMMARY |
|---|
| The protein encoded by this gene is involved in the acute-phase immunologic response to gram-negative bacterial infections. Gram-negative bacteria contain a glycolipid, lipopolysaccharide (LPS), on their outer cell wall. Together with bactericidal permeability-increasing protein (BPI), the encoded protein binds LPS and interacts with the CD14 receptor, probably playing a role in regulating LPS-dependent monocyte responses. Studies in mice suggest that the encoded protein is necessary for the rap |
| OBSERVATIONS |
|---|
| Complication | Evidence | PMID |
| Insulin resistance and inflammation | 1. Circulating LBP concentration was significantly increased in subjects with type 2 diabetes and dramatically increased in subjects with morbid obesity. | 22184060 |