| LCAT |
| LOCUS ID | 3931 | |||||||||||||
| GENE_SYMBOL | LCAT | |||||||||||||
| GENE NAME | lecithin-cholesterol | |||||||||||||
| SYNONYMNS | ||||||||||||||
| CHROMOSOME | 16 | |||||||||||||
| HOMOLOGENE ID | 68042 |
| microRNAs | NA | NA |
| GENE SUMMARY |
|---|
| This gene encodes the extracellular cholesterol esterifying enzyme, lecithin-cholesterol acyltransferase. The esterification of cholesterol is required for cholesterol transport. Mutations in this gene have been found to cause fish-eye disease as well as LCAT deficiency. [provided by RefSeq, Jul 2008] |
| OBSERVATIONS |
|---|
| Complication | Evidence | PMID |
| Cardiovascular | 1. The reduced levels of LCAT and ApoA1 observed in this study support the suggestion that T2DM patients with Hp2-2 phenotype could have altered RCT mechanism and increased risk of developing cardiovascular disease | 28416369 |
| Insulin resistance and inflammation | 1. Plasma GlycA was higher in MetS coinciding with higher hsCRP and LCAT activity (P < 0.01 for each). | 26081900 |